Synthesis of 4-Substituted Phosphacoumarins via Cross-Coupling of 4-Tosylphosphacoumarins with Organozinc Reagents

A series of 4-subsituted phosphacoumarin derivatives with potential biological and pharmacological activity has been synthesized through Negishi-type cross-coupling reactions of 4-tosylphosphacoumarins with organozinc reagents.