Meta-analysis for clinical effects of Shuxuetong and low-molecular-weight heparin in patients with deep vein thrombosis in lower limbs

Objective To systematically review the clinical effects of Shuxuetong and Low-molecular-weight Heparin(LMWH)in patients with deep vein thrombosis(DVT)in lower limbs. Methods The CNKI, Wanfang, VIP, SinoMed, PubMed, EMBASE, and ISI Web of Science databases were electronically searched from inception to February 3th, 2017, to collect the randomized clinical trials on the clinical effects of Shuxuetong and LMWH on DVT in lower limbs.Two investigators independently screened the literatures, extracted data and assessed the quality of enrolled studies.All analyses were performed using the Stata 11.0 software. Results Twenty studies involving 1 515 patients were finally included.The meta-analysis results showed that the total effective rate was significantly higher in Shuxuetong group than in LMWH drug control group(RR = 1.22, 95%CI: 1.13-1.32, P < 0.001). The subgroup analysis showed that there was no significant difference in total effective rate between the Shuxuetong alone group and LMWH alone control group(RR = 1.05, 95%CI: 0.98-1.12, P = 0.136). However, the total effective rate was significantly higher in Shuxuetong combined with LMWH group than in LMWH alone control group(RR = 1.30, 95%CI: 1.18-1.44, P < 0.001). Conclusions Shuxuetong combined with LMWH has better clinical effects than do LMWH alone group in treating patients with DVT in lower limbs. Key words: Venous thrombosis; Heparin, low-molecular-weight; Meta-analysis