Monte Carlo simulation of non-invasive glucose measurement based on FMCW LIDAR
2010
Continuous non-invasive glucose monitoring is a powerful tool for the treatment and management of diabetes. A glucose
measurement method, with the potential advantage of miniaturizability with no moving parts, based on the frequency
modulated continuous wave (FMCW) LIDAR technology is proposed and investigated. The system mainly consists of an
integrated near-infrared tunable semiconductor laser and a detector, using heterodyne technology to convert the signal
from time-domain to frequency-domain. To investigate the feasibility of the method, Monte Carlo simulations have been
performed on tissue phantoms with optical parameters similar to those of human interstitial fluid. The simulation showed
that the sensitivity of the FMCW LIDAR system to glucose concentration can reach 0.2mM. Our analysis suggests that
the FMCW LIDAR technique has good potential for noninvasive blood glucose monitoring.
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