Synthesis of planar chiral pseudo–ortho-substituted aryl[2.2]paracyclophanes by stepwise successive palladium-catalyzed coupling reactions

Abstract Planar chiral aryl[2.2]paracyclophanyl-thioureas and -phosphine with a pseudo–ortho substitution pattern have been designed and efficiently synthesized by stepwise successive palladium-catalyzed cross-coupling reactions.