진통, 소염효과 및 관절염에 미치는 소회향과 시라자의 효능 비교연구

Objectives : This experimental study was done to compare the efficacy of both Foeniculi Fructus and Anethi Fructus extract on analgesic effects, anti-inflammatory effects and arthritis. Methods : We studied the writhing syndrome in mice induced by 0.7% acetic acid for analgesic effects. We measured inhibitory effects on the paw-edema by acetic acid in rats to elucidate anti-inflammatory effects. And we studied the method of adjuvant arthritis to elucidate effects on arthritis. Results : In analgesic action on the writhing syndrome in mice induced by 0.7% acetic acid, Foeniculi Fructus and Anethi Fructus extract treated group showed significant decrease in cimparison with control group. In anti-inflammatory effects, Foeniculi Fructus extract treated group showed significant decrease at 180 minutes after inducing paw-edema in comparison with control group. And Anethi Fructus group showed significant decrease at 30 and 120 minutes after inducing paw-edema in comparison with control group. In the method of dajuvant arthritis, they significantly inhibited the hind paw edema in rats with Foeniculi Fructus extract from 15 days later to 21 days later after administration. And Anethi Fructus group extract treated group showed significant decrease at 7 days later after administration. In the level of leucocytes count and total protein, Foeniculi Fructus and Anethi Fructus extract treated group showed increase in comparison with control group, but these results didn`t show significant increase. In the level of CRP, Foeniculi Fructus and Anethi Fructus extract treated group showed decrease in 00comparison with control group, but these results didn`t show significant decrease. In the level of glucose and platelet count, Foeniculi Fructus extract treated group showed increase in comparison with control group, but these results didn`t show significant increase. Anethi Fructus extract treated group showed decrease in comparison with control group, but these results didn`t show significant decrease. Conclusion : Reviewing these experimental results, it appears that Foeniculi Fructus and Anethi Fructus Extract have equal efficacy on analgesic effects, anti-inflammatory effects and arthritis.