Lanostane triterpenoids, spiro-astraodoric acid, and astraodoric acids E and F, from the edible mushroom Astraeus odoratus

Abstract Three lanostane-type triterpenoids, spiro-astraodoric acid ( 1 ), and astraodoric acids E and F ( 2 and 3 ), together with 6 known compounds ( 4 – 9 ) were isolated from fruit bodies of an edible mushroom, Astraeus odoratus . Compound 1 possessed an unusual spirocyclic lanostane triterpenoid structure. Their structures were determined by spectroscopic analysis and the absolute configuration of spiro-astraodoric acid and astraodoric acids was described herein. Cytotoxicity of the isolated compounds was tested against six human cancer cell lines.