Serological detection and partial characterization of the common-ALL-cell associated antigen in the serum of cALL-patients

Abstract Sera of patients with common-ALL were found to contain a glycoprotein reacting with antibodies directed to common-ALL associated antigen (Ag cALL). The identification of this protein which has an apparent molecular weight of 125,000 and a binding specificity to lens culinaris lectin is reported. These data are in good accordance with those estimated for the corresponding antigen solubilized from cALL cells as well as those obtained from cultured cell-lines established from leukemic cells and indicate an in vivo shedding or secretion of the molecule.