DIFFERENT ANESTHESIA IN RAT INDUCES DISTINCT INTER-STRUCTURE BRAIN DYNAMIC DETECTED BY HIGUCHI FRACTAL DIMENSION

The complexity, entropy and other non-linear measures of the electroencephalogram (EEG), such as Higuchi fractal dimension (FD), have been recently proposed as the measures of anesthesia depth and sedation. We hypothesized that during unconciousness in rats induced by the general anesthetics with opposite mechanism of action, behaviorally and poligraphically controlled as appropriately achieved stable anesthesia, we can detect distinct inter-structure brain dynamic using mean FDs. We used the surrogate data test for nonlinearity in order to establish the existence of nonlinear dynamics, and to justify the use of FD as a nonlinear measure in the