Quantitative assessment of liver parenchymal perfusion in rabbit liver fibrosis model by contrast-enhanced ultrasonography

Objective:Using real time gray scale contrast enhanced ultrasonograpy(CEUS)to assess quantitatively the parenchymal perfusion of rabbit liver fibrosis model.Methods:Contrast-enhanced ultrasound quantitative assay was performed in 30 thioacetamide(TAA)-induced rabbit liver fibrosis model,and the results were compared with pathology examination.Results:The peak intensity(PI) decreased gradually with the increase of liver fibrosis Sa～Sd).With the exception between group Sb and Sc,the peak intensity between these groups differed significantly(P0.05).The contrast agent arrival time(AT) differed significantly(P0.05) between group Sa,Sb and Sc with a gradually decreasing trend.The time to peak intensity(TTP) of Sd group was significantly higher than the other groups.Conclusions:Degree of liver fibrosis could be evaluated by real time gray scale contrast-enhanced ultrasonography.