Prognosis factors of patients with primary aldosteronism after adrenalectomy

Objective To investigate the influential factors for recovery of blood pressure in patients with primary aldosteronism(PA) after adrenalectomy.Methods The clinical and follow up data(6-36 months)of patients with PA,who underwent adrenalectomy between Jan.2009 and Mar.2012 were analyzed retrospectively.Factors which would be likely to influence prognosis were collected,and those which showed statistical significance by One-Way ANOVA analysis were screened,followed by further logistic regression analysis to obtain the independent factors related to outcome of these patients.Results Among the 93 PA patients after adrenalectomy,according to the imaging study and pathology results,59 patients were with adrenocortical adenomas(63.44％),27patients with unilateral adrenal hyperplasia(29.03％),and 7 patients with idiopathic hyperplasia(7.52％).43 patients (46.24％)returned to normal blood pressure after surgery,47 patients (50.54％)had blood pressure relief,and 3 patients(3.22％)had no improvement of blood pressure.Logistic regression analysis showed the influential factors were as following:history of hypertension,grade of hypertension after receiving medical treatment,and aldosterone renin ratio before surgery.Conclusions Recovery of blood pressure can be evaluated based on hypertension history,hypertension grade after receiving medical treatment,and aldosterone-to-renin ratio for patients needing adrenalectomy.In addition,the follow-up and life style intervention should be strengthened,and comprehensive treatment should be improved. Key words: Primary aldosteronism;  Blood pressure;  Prognosis;  Logistic regression analysis