Особенности тканевой экспрессии ферментов протеолиза внеклеточного матрикса и их ингибиторов больных раком мочевого пузыря.

Objectives . Levels and expression of matrix metalloproteases 2 (MMP-2), MMP-9, MMP-14 and tissue inhibitor of metalloproteinases 1 (TIMP-1), TIMP-2 were studied by immunohistochemistry in tumor and surrounding tissues in 73 patients with superficial bladder cancer (BC) ТаN0M0 and Т1N0M0 depending on the disease characteristics.  Results. The study showed the initial increase in the number of tumor cells expressing MMP-2, MMP-9 and MMP-14 and their tissue inhibitors, compared to histologically unchanged tissues and tumor-adjacent tissues. The number of MMP-9 producing tumor cells was maximal. Tissue expression of TIMP-1 and TIMP-2 in tumor cells in superficial BC patients was higher than in unchanged tissues and in tumor-adjacent tissues. The ratio of MMP and TIMP expression differed, and the proteolytic potential of MMP was higher than that of TIMP. Conclusion. The study demonstrated the influence of the primary bladder cancer stage (from Ta to T1), tumor differentiation grade (from G1 to G2) and prognosis of the disease course (from favorable to intermediate) on the enhancing expression of MMP-9 and TIMP-1 in tumor tissues in superficial BC.