Activity of human natural killer cells against target cells differing in sensitivity to interferon

An important factor in the assessment of natural cytoltoxicity (NCT) of human lymphocytes is the choice of target cells (TC) used to obtain information about the mechanisms of realization of the cytotoxic potential of natural killer (NK) cells. Most investigations devoted to the study of active human NK cells in various physiological and pathological states have been conducted on a model culture of human K-562 erythromyeloblasts. Several investigators have nsed lines of T lymphoblasts (MOLT 4) and B lymphoblasts (Raji, Daudi, RPMI-1788) as TC or NK cells. Human lines of TC BT-20 (mammary gland carcinoma), MA-160 (prostatic adenoma), H}~MS (melanoma), etc. have been used in separate investigations.