BRINE SHRIMP LETHALITY BIOASSAY OF THREE TERPENES ISOLATED FROM THE BARK OF ZANTHOXYLUM BUDRUNGA WALL: A CYTOTOXIC EVALUATION OF PLANT BIOACTIVE PRINCIPLES

The cytotoxic activity of free terpenes isolated from the bark of Zanthoxylum budrunga Wall, used in folk medicine in Bangladesh, was evaluated by Brine Shrimp Lethality Bioassay. The LC50 values of ZB-1, ZB-2 and ZB-3 were found to be 11.49, 19.99 and 13.19 µg/ml, respectively and the LC90 values were found to be 49.24, 52.77 and 49.23 µg/ml, respectively.