Биохимические особенности процессов свободнорадикального окисления и локальной продукции гуморальных факторов защиты в ротовой полости при ишемической болезни сердца с нормальным и нарушенным углеводным обменом

As a result of the research found that coronary heart disease (CHD) with normal and impaired carbohydrate metabolism in the oral cavity is an imbalance in the development of all parts of the local system of non-specific defense. In this case, the leading pathobiochemical shifts were decrease in oral fluid (OF) activity of key enzymes of anti-radical protection (catalase and superoxide dismutase), the depletion of the antioxidant capacity of a low-molecular-level (glutathione) of the endogenous antioxidant system, which is accompanied by increased inflammation in the oral cavity and is characterized by an increase in the content of a number of immunoglobulins (IgM and secretory IgA). The consequence of these processes is a significant increase in the destruction of periodontal tissues due to the processes of peroxide modification of biomolecules. The results also confirmed the possibility of the use of OF in clinical practice to perform non-invasive differential diagnosis and monitoring of patients with CHD, especially in the presence of associated disorders of carbohydrate metabolism.