Influenza Antiviral Activity of Br-Containing [2R,4R(S),4aR,7R,8aR]-4,7-Dimethyl-2-(Thiophen-2-YL)Octahydro-2H-Chromen-4-Ols Prepared from (–)-Isopulegol

Influenza A (H1N1) antiviral activity of compounds with an octahydro-2H-chromene skeleton that were prepared by reacting the monoterpenoid (–)-isopulegol and thiophenecarboxaldehyde and its derivatives was studied for the first time. The 5-bromothiophene-2-carboxaldehyde derivative exhibited the greatest antiviral activity.