Protein having the Tpo activity

(57) Abstract: The present invention, encodes a thrombopoietin (TPO) or a derivative thereof, TPO polypeptide having the amino acid sequence 1-332 of and SEQ ID NO: 6 having a biological activity of specifically stimulating or enhancing platelet production DNA molecules, a method of manufacturing a TPO polypeptide, TPO polypeptide specifically immunoreactive antibodies, pharmaceutical compositions containing a TPO polypeptide, the TPO polypeptide to treat platelet disorders such as thrombocytopenia on how to use.