Nutrigenomics, Inflammaging, and Osteoarthritis: A Review

The global incidence of age‐related diseases of the bone, joint, and muscle is steadily rising, seriously affecting the health of millions of people across the world. According to the United Nations (UN) (www.un.org) and the World Health Organization (WHO) (www.who.int) musculoskeletal and arthritic conditions are leading causes of morbidity and disability throughout the world, giving rise to enormous healthcare expenditures and loss of work (sources: The Arthritis Foundation (AF) and WHO: Ehrlich, 2003; Salminen et al., 2012a; Symmons et al., 2000; Woolf et al., 2003; 2, ). Many types of rheumatic diseases and arthritic conditions are essentially “inflammatory” disorders wherein that inflammation promotes disease progression. The term “arthritis” characterizes a group of conditions involving inflammatory damage to synovial joints (Di Paola et al., 2008). Arthritis literally means inflammation (itis) of the joints (arthr). It involves pain, redness, heat, swelling, and other harmful effects of inflammation within the joint. There are over 200 different forms of arthritis. Nutrigenomics, Inflammaging, and Osteoarthritis: A Review