Regulatory mechanisms for the differentiation of Th17 cells and their roles in asthmatic airway inflammation

Th17 cells belong to CD4+ T cell subsets, which are closely associated with allergic diseases and autoimmune diseases.Bronchial asthma(asthma) is a common childhood disease.Asthma is an allergic disease with dominant Th2-type immune response.However, Th17 cell subset and their cytokines have attracted more and more attention because of their roles in the pathogenesis of asthma.In this article, the regulatory mechanisms of the differentiation, the relationship with other subsets of Th17 cells, as well as their roles in asthmatic inflammation were reviewed, which may offer a better understanding of asthma and provide new directions for the treatment of asthma. Key words: Th17 cell; Bronchial asthma; Airway inflammation