Saturated long-chain esters of isopulegol as novel permeation enhancers for transdermal drug delivery.

Purpose Saturated long-chain esters of isopulegol were synthesized and their activities as permeation enhancers for transdermal delivery of amlodipine and flurbiprofen were investigated, in contrast to the saturated fatty acids and isopulegol, as well as their physical mixtures.