Importance and applications of cell- and tissue-based in vitro models for drug permeability screening in early stages of drug development
2016
This chapter discusses the role of cell- and tissue-based in vitro models in drug permeability screening during the early stages of drug development. A general description of different experimental methods as well as all factors affecting the drug permeability and the permeability calculation procedures are described in detail. Finally, the importance of standardization protocols for in vitro methods, the application of the “three Rs” policy in experimental procedures, and the biosecurity systems in most of the cell and tissue in vitro methods are clearly elucidated.
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