Design of the novel protraction mechanism of insulin degludec, an ultra-long-acting basal insulin.
2012
Purpose
Basal insulins with improved kinetic properties can potentially be produced using acylation by fatty acids that enable soluble, high-molecular weight complexes to form post-injection. A series of insulins, acylated at B29 with fatty acids via glutamic acid spacers, were examined to deduce the structural requirements.
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