Iridium‐Catalyzed Asymmetric Hydrogenation of 3‐Substituted 2H‐1,4‐Benzoxazines
2012
The highly enantioselective hydrogenation of 3-aryl-2H-1,4-benzoxazines was achieved using the (cyclooctadiene)iridium chloride dimer/(S)-SegPhos/iodine {[Ir(COD)Cl]2/(S)-SegPhos/I2} system as catalyst with up to 92% ee. The 3-styryl-2H-1,4-benzoxazine derivatives were also hydrogenated by the iridium catalyst and Pd/C in two consecutive steps whereby 9395% ee values were obtained.
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