Structural Analyses of Sugar Branched Cyclodextrin Derivatives by the Post-Source Decay Fragment Method in MALDI-TOF Mass Spectrometry

Post-source decay fragment analyses by MALDI-TOFMS were applied to the sugar-branched s-cyclodextrin (CD) derivatives. In the fragment spectra, all possible fragment ions larger than trisaccharide produced by the cleavage of glycosidic linkage were clearly observed. The detailed ion intensity analyses enable us to distinguish the ions produced from branched and CD moieties because the ion intensities were influenced by the structure. The relative intensities of the ions produced from s-CD moiety have the characteristically cleavaged pattern which was common in the branched s-CDs.