251 Post-coital bleeding and younger age are risk factors for high-grade dysplasia in women with biopsy proven low-grade squamous intraepithelial lesions

Objectives Biopsy proven newly diagnosed Low-grade Squamous Intraepithelial lesions(LGSIL), are considered reversible lesions and as such are usually treated conservatively with follow-up or ablation. In this study we aimed to evaluate the outcome of women with LGSIL who underwent surgical conization, and assess risk factors for higher risk disease. Methods We performed a retrospective study of all patients who underwent surgical conization for LGSIL disease, in one university affiliated medical center (2012–2017). Study group was defined as patients who had their histological classification upgraded, and control group as patients who were either downgraded or diagnosis remained. Demographics, histological outcome and indications were compared between groups. Results Overall, 111 patients met inclusion criteria of whom 44(39%) were histologically upgraded, 1 patient was found to have Adenocarcinoma of the cervix. Upgraded women were younger (34y vs 44y, p Conclusions Contrary to common practice, in this study, younger women with a biopsy diagnosis of LSIL, should be evaluated for high risk disease especially if they report PCB.