Abstract 14116: Effects of Statin Intensity and Low-density Lipoprotein Cholesterol Lowering in Korean Patients With Chronic Ischemic Heart Disease and Very Low Low-density Lipoprotein Cholesterol

Introduction: Current guidelines on lipid management emphasize LDL-C lowering >50% of baseline levels with intensive statin regimens in patients with coronary artery disease. However, whether this strategy is beneficial also in patients with very low LDL-C has not been proven. Furthermore, controversy remains on the optimal statin intensity for Asians in whom outcome data of lipid therapy are highly limited. Methods and Results: Totally, 3867 patients with chronic ischemic heart disease were initially screened. Among them, 393 subjects(age: 66 years; males: 68%) who showed baseline LDL-C <80 mg/dL without lipid lowering medications were finally included. Patients were retrospectively classified to 4 groups according to statin intensity they received : no (n=35), Moderate-low (atorvastatin 10mg or similar, n=135), moderate-high (atorvastatin 20 mg or similar, n=177), or high (atorvastatin 40-80 mg or similar, n=46) intensity. Patients took blood tests every 3-6 months and were clinically followed-up for ma...