Results of a comprehensive pharmacogenetic analysis of dihydropyrimidine dehydrogenase in patients treated with fluoropyrimidines and patterns of polymorphisms partially related to treatment tolerability.

Marzia Del Re,Marta Schirripa,Angela Michelucci,Marta Cubelli,S Magagna,Santino Minichillo,Fotios Loupakis,Paolo Simi,Claudio Zamagni,Alfredo Falcone,Romano Danesi

Results of a comprehensive pharmacogenetic analysis of dihydropyrimidine dehydrogenase in patients treated with fluoropyrimidines and patterns of polymorphisms partially related to treatment tolerability.

2012

Marzia Del Re
Marta Schirripa
Angela Michelucci
Marta Cubelli
S Magagna
Santino Minichillo
Fotios Loupakis
Paolo Simi
Claudio Zamagni
Alfredo Falcone
Romano Danesi

e13057 Background: Metabolic clearance of fluoropyrimidines is highly dependent on the rate-limiting enzyme dihydropyrimidine dehydrogenase (DPD). Deficiency of DPD is associated with drug accumula...

Keywords:

Pharmacogenetic Analysis
Oncology
Medicine
Internal medicine
Tolerability
Dihydropyrimidine dehydrogenase
Drug
in patient
Enzyme
Pathology
Pharmacology

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