Virus envelope tissue factor promotes infection in mice
2019
Background:
Tissue factor (TF) is the essential cell-surface initiator of coagulation and mediates cell signaling through protease activated receptor (PAR) 2. Having a diverse cellular distribution, TF is involved in many biological pathways and pathologies. Our earlier work identified host-cell derived TF on the envelope covering several viruses and showed its involvement toward enhanced cell infection in vitro.
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