Влияние изатина и бромизатина на ионные каналы нейронов моллюска

Changes in transmembrane calcium, sodium and potassium ionic currents during extracellular administration of heterocyclic compounds, isatine and bromisatine, in concentrations from 10-8 till 10-3 моl/l have ben studied. Method of intracellular dialysis and fixation of membrane potential in the mollusk Lymnaea stagnalis neurons have been used. Both compounds produced dose-dependant and reversible inhibitory action on neuron currents amplitude. It was – 5-35% from control indices in all intervals of concentrations, bromisatine inhibiting action being more significant. Kinetics of currents development do not change, but the shift of voltage-amper membrane characteristics to the right according to axis of potentials by 5-10 mV was registered. Therefore, both isatine and bromisatine possess membranotropic activity.