Manifestaciones cutáneas de amiloidosis sistémica en tres pacientes Cutaneous manifestations in three patients with systemic amyloidosis / Manifestações cutâneas de amiloidosis sistémica em três pacientes

Systemic amyloidosis is a group of heterogeneous diseases caused by tissue deposition of misfolded proteins. We report 3 cases of patients with systemic amyloidosis. Diagno sis in all cases was conArmed by biopsy. Here, we also brieAy review the pathogenesis, diagnosis, treatment, and clinical manifestations, with a particular focus on cutaneous manifestations. Since such lesions appear early in the disease, we consider that accurately identifying them can have an impact on the prognosis of this affection.