Stereoselective Inhibition of Neuronal Sodium Channels by Local Anesthetics Evidence For Two Sites of Action

The objective of this study was to determine if the «tonic,» resting inhibition of Na + channels by local anesthetics results from binding at a site different from that for «phasic,» use-dependant inhibition. Stereoselective actions of four local anesthetics were examined in isolated frog peripheral nerve and single Na + channels