The clinical significance of endothelin-1, creactive protein and interleukin-6 levels in children with hand, foot, and mouth disease

Objective To explore the clinical significance of endothelin 1(ET-1), creactive protein(CRP) and interleukin-6(IL-6) levels in children with hand-foot-and mouth disease. Methods All 120 children with hand-foot-and mouth disease treated in our hospital from January 2015 to November 2016 were recruited for this study.According to the clinical characteristics, patients were divided into normal group (n=39), severe group (n=60), and critical group (n=21). Heart rate, white blood cell count, blood glucose, serum ET-1, serum CRP, IL-6 levels of the patients were observed. Results Compared with normal group and severe group, patients in the critical group were characterized with young age, high blood sugar, and fast heart rate.White blood cell count of the patient in critical group is higher than that of normal group.Children in severe group showed severely elevated heart rate, white blood cell count, blood glucose levels, compared to the patients of normal group.ET-1 of the critically ill patients was significantly increased compared with that of the patients in other groups.Children in the critical illness group showed higher levels of CRP after the admission at day 1, 3, and 7.ET-1, CRP, and IL-6 were independent risk factors for hand-foot-and mouth disease patients(P<0.05). Conclusions The detection of serum IL-6, CRP, and ET-1 can provide useful information for the clinical judgement on the children with hand-foot-and mouth disease. Key words: Hand foot mouth disease; Endothelin-1; Creactive protein; Interleukin-6