Carbetocin and preparation method thereof

2014 
The invention belongs to the technical field of medicine, relates to an oxytocin analogue, particularly relates to a carbetocin and more particularly relates to a carbetocin crude drug having an excellent pharmaceutical performance. The carbetocin disclosed by the invention can be used after cesarean under selectively epidural or spinal anesthesia to prevent uterine inertia and postpartum hemorrhage. The invention also relates to a preparation method of the carbetocin. Furthermore, the invention also relates to a pharmaceutical composition, particularly an injection, prepared from carbetocin serving as a crude drug. According to the carbetocin which can be used as medicinal crude drug, the content of acetic acid does not exceed 5.0%, the content of moisture does not exceed 6.0% and the content of C45H69N11O12S is 95.0%-105.0%.
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