Multilamellar or multivesicular vesicles
1987
Recently attention in liposome preparation
technology has been focused on the preparation of
liposomes with a large number of bilayers.
These liposomes offer the possibility to encapsulate
large amounts of hydrophobic drugs. All
methods used to prepare these vesicles are modifications
of the method used to produce reversephase
evaporation vesicles (REV), as described
first by Szoka and Papahadjopoulos (1978). The
names for these multi-layered vesicles are: stable
plurilamellar vesicles (SPLV),
multilayered REV (MLV-REV) and multilamellar vesicles.
In order to avoid confusion we will refer to the
vesicles prepared by Bangham et al. as
multilamellar vesicles (MLV) and to those multilayered
vesicles prepared by emulsion techniques
as REV-MLV.
Gruner et al. compared the physical
characteristics of MLV and SPLV. They found
that these vesicles had different properties for
stability, entrapment efficiency and biological effects,
even if they were made from the same
materials and appeared quite similar in the electron
microscope.
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