Capillaryガスクロマトグラフ/質量分析(GC/MS)を用いたヒト尿中ジアセチルモルヒネの検出

The results for the qualitative and quantitative detection of diacetylmorphine (heroin) and its metabolites in the urine samples of heroin abusers are presented. The heroin and its metabolites were directly extracted with chloroform-isopropanol (3 : 1, pH ≒ 9.5, 20°C) from the urine samples. The heroin and its metabolites were separated by capillary GC and identified mass spectrometrically by full mass spectra. The heroin and its metabolites levels were determined by quantitative selected ion monitoring (SIM). As the results, heroin, 6-acetylmorphine, morphine, acetylcodeine and codeine were detected by capillary GC/MS from the urine sample of heroin abuser. The above data suggest that the capillary GC/MS method is useful for the detection of heroin in the urine samples of heroin abusers as evidence for drug use.