Multimodal imaging platform for image-guided surgery: application to blood perfusion assessment

Despite the technological evolutions that transform the operating rooms nowadays, a major clinical need remains: surgeons need to distinguish healthy from diseased tissues while performing a procedure. Tissue status assessment procedures such as blood perfusion monitoring require objective input that can potentially be obtained with fluorescence imaging and oxygenation imaging. We developed a multimodal imaging platform for performing widefield quantitative oxygenation imaging and fluorescence imaging in a clinical environment. We demonstrate in-vivo the impact of widefield quantitative oxygenation imaging on blood perfusion assessment. Fluorescence imaging provided by the system is used in complement to confirm the outcome of oxygenation imaging.