Syntheses of Fmoc-alfa-aminoalkyltetrazoles and Tetrazole Analogue of Leu-enkephalin

Five Fmoc-a-aminoalkyltetrazoles were synthesized starting from Fmoc-α-amino acids. Fmoc-LeuT was applied in synthesis of tetrazole analogue of Leu-enkephalin by solid phase peptide synthesis (SPPS), as well as in solution. Radioreceptor assays showed high affinity of [LeuT 5 ]-enkephalin for opiate receptors.