Incident Rheumatoid Arthritis in Human Immunodeficiency Virus Infection: Epidemiology and Treatment.

OBJECTIVE To assess the incidence, presentation, and management of RA in persons with HIV (PWH), including use of disease-modifying anti-rheumatic drugs (DMARDs) in this immunosuppressed population. METHODS Patients were included from the Veterans Aging Cohort Study, a longitudinal cohort of Veterans with HIV and matched uninfected Veterans. We identified patients with ≥1 rheumatologist-generated International Classification of Diseases (ICD) code for RA and a measurement of rheumatoid factor (RF) or anti-CCP antibodies. Charts were reviewed using the 2010 RA Classification Criteria to identify incident RA. We recorded use and adverse effects of DMARDs during the first contiguous (no interruption greater than 6 months) course. RESULTS We included 56,250 PWH and 116,944 uninfected persons over 2,384,541 person-years. Of 2,748 patients with an RA ICD code, incident RA was identified in 215 patients, including 21 PWH. The incidence rate ratio of RA in PWH vs. uninfected was 0.29 (95% CI 0.19-0.48). Most patients (88%) with RA were seropositive. However, high autoantibody titers were less common in PWH: 5% (1/21) of PWH had both high titer anti-CCP and RF, compared to 41% (82/194) of uninfected. DMARDs were prescribed for 71% (15/21) of PWH with RA, compared to 94% (183/194) of uninfected. Among 10 PWH prescribed DMARDs, we found no signal for worse infectious safety profile compared to 158 HIV-negative controls. CONCLUSION Incident RA was less common in PWH than in matched controls. PWH with incident RA had less positive autoantibody profiles than controls and were prescribed DMARDs less frequently.