Predisposing factors for bacteremia in patients with community-acquired pneumonia and positive pneumococcal urinary antigen

Objective: The presence of bacteremia in pneumococcal community-acquired pneumonia (P-CAP) is associated with more morbidity and poorer outcome. Our aim was to identify factors associated with bacteremia in patients with P-CAP diagnosed by positive urinary antigen (+UA). Methods: Prospective observational study, including all immunocompetent patients hospitalized for P-CAP (diagnosed by +UA on admission) in the pneumology service of 2 hospitals for a 15-year period. Blood cultures (BC) were taken from all patients. Patients were divided in 2 groups according to the BC results. Univariate and multivariate analysis were performed. Results: We included 957 patients with P-CAP; 342 (35.7%) with positive BC. Figure1: main characteristics of both groups. Figure2: multivariate analysis of factors associated with bacteriemia. Conclusions : - Neoplastic disease, BUN ≥ 30, Na - Pneumococcal vaccine, previous antibiotic treatment and COPD were protective factors for bacteremia in our patients.