Moxonidine Therapy, Serum Leptin Concentration, Lipid And Carbohydrate Metabolism In Hypertensive Postmenopausal Women With Metabolic Syndrome: Pp.34.419

To evaluate influence of moxonidine on serum leptin concentration, lipid and carbohydrate metabolism in hypertensive postmenopausal women with metabolic syndrome (MS). 26 hypertensive (AH grades 1–2) postmenopausal women with MS 52,5+/−0,4 years old. MS was diagnosed according to ESC-ESH (2007) criteria. Patients were treated with moxonidine (200–600 mcg/day orally) during 12 weeks. Serum leptin and plasma insulin levels were determined by ELISA. Serum lipids were defined by immunoenzymatic assay. The homeostasis model assessment (HOMA-IR and HOMA-FB) was applied to assess insulin resistance and insulin secretion. Statistical analyses were performed using SPSS 17.0 for Windows (SPSS, Inc., Chicago, IL, USA). Postmenopausal hypertensive women with MS had high level of serum leptin concentration (107,2+/−12,0 ng/ml), HDL cholesterol concentration was 1,3+/−0,09 mmol/l, glucose plasma was 5,33+/−0,10 mmol/l, HOMA-IR - 3,8+/−0,3 and HOMA-FB index was 204,7+/−30,1. Plasma glucose level >5,6 mmol/l had 8 (27%) women, dyslipidemia was revealed in 22 (84,6%) patients. HOMA-IR index elevation was revealed with 19 (73%) patients. Moxonidine therapy did not influenced serum leptin level - 107,2+/−12,0 ng/ml vs 101,4+/− 11,7 ng/ml (p = 0,06); HDL cholesterol increased from 1,3+/−0,09 mmol/l to 1,5+/−0,09 mmol/l (p < 0,05), LDL cholesterol, triglycerides and total cholesterol did not changed, HOMA-IR index did not changed, and plasma glucose level did not changed (5,33+/−0,10 mmol/l vs 5,15+/−0,13 mmol/l; p = 0,07). By the end of 12 weeks of moxonidine therapy HOMA-FB index increased from 204,7+/−30,1 to 222,3+/−27,8 (p < 0,05). In hypertensive postmenopausal women with metabolic syndrome moxonidine therapy improved some parameters of lipid composition (HDL cholesterol elevation), and increased HOMA-FB index, but serum leptin, plasma insulin and plasma glucose levels did not significantly changed.