A Multiphase Flow Simulation for a Cells-on-a-Chip Device

Microfluidics-based microscale cell culture (cells-on-a-chip) provides a well-controlled system with physiological realistic parameters that emulates the organ-to-organ network of the human body. In the microenvironment, the in vivo situation can be resembled closely by controlling the chip geometry, medium flow behavior, medium-to-cell ratio, and other fluid dynamic parameters. This study is to develop a multiphase model to simulate the flow in such a device. The cell deposition rate influenced by the flow shear is discussed. The physics of fluid dynamics for each of the above mentioned parameters is investigated.Copyright © 2016 by ASME