The New Anticancer Drug Ilmofosine Enhances the Activity of CIS-Platin and Reverses Multidrug Resistance

It is well established that the alkyllysophospholipid ilmofosine (BM 41 440) exhibits antiproliferative activity on tumor cells, but not on bone marrow. Here we demonstrate synergism in antitumor activities of a combination of ilmofosine with cis-platin. We also show that 0.1 μM ilmofosine reverses the multidrug resistance of KB-8-5 cells to the sensitivity of KB-3-1 cells.