Tolyprolinol, a new dipeptide from Tolypocladium sp. FKI-7981

A new dipeptide, named tolyprolinol, was isolated from the static culture of a fungus, Tolypocladium sp. FKI-7981. The structure of tolyprolinol was elucidated as N-acetyl-l-phenylalanyl-l-prolinol. It showed moderate antimalarial activity but did not show cytotoxicity or any other antimicrobial property.