Diagnostic Value of Histamine and Tryptase Concentrations in Severe Anaphylaxis With Shock or Cardiac Arrest During Anesthesia

Background:The diagnosis of acute life-threatening allergic reactions during anesthesia relies on clinical signs, histamine and/or tryptase measurements, and allergic testing. In patients who die after the reaction, skin tests cannot be performed, and the effect of resuscitation manoeuvres on mediat