Direct Regiospecific and Highly Enantioselective Intermolecular α-Allylic Alkylation of Aldehydes by a Combination of Transition-Metal and Chiral Amine Catalysts.

The present allylic alkylation of various linear aldehydes (II), catalyzed by an achiral palladium complex and a chiral amine as co-catalyst, gives the corresponding alcohols after in situ reduction with NaBH4.