Insilico designing of Pyrazol-1-Yl Azetidin-2-One derivatives as drug like molecules for possible inhibition of Anti Microbial 3GI9, 4AE5, 3FHU and 5COX target Proteins

Two series of 1- [ [3-(substituted phenyl)-5-substituted-4,5-dihydro-1H Pyrazol-1-yl] Carbonothionyl]-3-chloro-4- (Fuan-2-yl)] Azetidin-2-ones derivates were interacted through inter o r intra molecular hydrogen bonding by the enzymatic keys and ADME toxicity, solubility, Drug-score and Biological activities studies, which indicated that the compounds 4(P 1-P7, P 11 -P77 ) have drug likeness properties . The enzymatic keys are the target proteins or receptors of E.coli (3GI9), S.a. (4AE5), S.typhi (3FHU), cyclooxygenase (5COX) and helped for designing of the compounds 4 (P1-P7, P11-P77) for better activities by the MVD-5.0.5 software.