The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition

Henrik Sperber,Julie Mathieu,Yuliang Wang,Amy Ferreccio,Jennifer Hesson,Zhuojin Xu,Karin A. Fischer,Arikketh Devi,Damien Detraux,Haiwei Gu,Stephanie L. Battle,Megan Showalter,Cristina Valensisi,Jason H. Bielas,Nolan G. Ericson,Lilyana Margaretha,Aaron M. Robitaille,Daciana Margineantu,Oliver Fiehn,David M. Hockenbery,C. Anthony Blau,Daniel Raftery,Adam A. Margolin,R. David Hawkins,Randall T. Moon,Carol B. Ware,Hannele Ruohola-Baker

The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition

2015

By comparing the metabolomes, transcriptomes and epigenomes of human pluripotent stem cell lines, Sperber et al. show that interplay between the metabolome and histone modifications drives the metabolic switch from naive to primed pluripotency.

Keywords:

Molecular biology
Cell biology
Induced pluripotent stem cell
Cellular differentiation
Histone
Epigenetics
Embryonic stem cell
Metabolome
Transcriptome
Metabolomics
Biology
Wnt signaling pathway
Histone methylation
Cell type

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