원저 : 정맥성 궤양 환자에서의 활성형 C 단백질 저항성 및 Leiden 돌연변이 유병률에 관한 연구

Background : Recently, resistance to activated protein C(APC) is known to be an important risk factor for venous leg ulcers. Leiden mutation in clotting factor V is the most common genetic defect leading to APC resistance in western countries. Until now, the prevalence of APC resistance and Leiden mutation in Korean patients with venous ulcers has been ill defined. Objective : We performed this study in order to investigate the prevalence of APC resistance and Leiden mutation in Korean patients with venous ulcers. Methods : The functional analysis for APC resistance(APC resistance ratio) and genetic study for Leiden mutation were conducted in 40 patients with venous ulcers. Results : 1. Of the 40 patien with venous ulcers, resistance to APC was documented in 11 individuals (27.5%). 2, We could not find factor V Leiden mutation in 40 patients. 3, Patients with APC resistance more frequently represented venous thrombosis than in their non-APC resistant counterparts. Conclusion : APC resistance may be one of the thrombophilic defects in relation with venous ulcers in Korea. However, Leiden mutation may be rate in Korean patients with venous ulcers than in Caucasians. These findings suggested that the other genetic or non-genetic factors may be involved in the pathogenesis of APC resistance in Korea.