Whole-body FDG-PET versus Tc-99m MDP bone scintigraphy for detection of bone metastases in patients with lung cancer

2023 Background: Lung caner is the most common cancer in the world accounts for 12.3% of all new cancer cases with millions of deaths per year. For the prognosis and the therapy strategies, the evaluation of tumor spread is important. Recently, 18F-2-fluro-deoxy-D-glucose (FDG) positron emission tomography (PET) is used to detect local and distant metastases. The aim of this study was to evaluate the effect of adding whole body FDG PET to conventional bone scintigraphy for staging and detection bone metastasis in patients with lung cancer. Methods: We evaluated and compared the results of both FDG PET and bone scintigraphy in 132 lung cancer patients who had suspected local or distance metastases before treatment. Bone scintigraphy and FDG PET was performed blinded to the findings of history and physical examination. The combined results of magnetic resonance imaging (MRI), computed tomography (CT) and the subsequent clinical course served as the gold standard for the identification of bone metastases. Re...