Changes of Vascular Endothelial Growth Factor in Serum and Urine in Children with Steroid-Sensitive Nephrotic Syndrome

Objective To investigate the changs of serum and urine vascular endothelial growth factor(VEGF) in children with steroid-sensitive nephrotic syndrome(SSNS) at their active and remission stage.Methods Serum and morning urine levels of VEGF were assayed by Liquichip in 30 patients with SSNS at the active and remission stage and 30 normal age-and sex-matched controls.Results Serum levels of VEGF in patients at the active stage [(186.62±106.21) ng/L] were significantly higher those that at the remission stage [(118.75±73.08) ng/L] and than those in control group [(108.64±54.75) ng/L](P0.05).There was no statistical difference in the serum levels of VEGF between the patients at the remission stage and healthy controls(P0.05).Morning urine levels of VEGF in patients at the active stage [(201.66±100.46) ng/L] were significantly higher than those at the remission stage [(116.35±55.99) ng/L] and than those in control group [(99.94±42.07) ng/L](P0.05).There was no statistical difference in the morning urine levels of VEGF between the patients at the remission stage and healthy controls(P0.05).Conclusions Serum and morning urine levels of VEGF are significantly elevated in patients with SSNS,however they are significantly lower after the treatment of steroid.There is no obvious difference between the patients at the remission stage and healthy controls.VEGF involves pathogenetically and physiologically in SSNS during its onset and growth.