MOLECULAR AND EPIDEMIOLOGICAL FEATURES OF GROUP INCIDENCE OF ENTEROVIRUS INFECTION CAUSED BYTHE COXSACKIE A6 VIRUS AMONG THE POPULATION OF THE RUSSIAN FAR EAST IN 2016-2017

Objective. There are favorable conditions for an annual seasonal increase in the incidence of enterovirus infection in the Russian Far East. Methods. Molecular typing of PCR-positive samples of biological material from four outbreaks of enterovirus infection registered in the Far East in 2016-2017 was carried out. Results. The cause of all flares was the Coxsackie A6 virus. Phylogenetic analysis of the strains revealed their similarity to the Coxsackie A6 virus, which circulated in 2016-2017 in other regions of Russia, as well as in Asian countries in 2009-2013. Conclusions. With molecular typing, the Coxsackie A6 virus was identified in 2013 in five of the nine administrative regions of the Russian Far East and by 2017 it spread throughout its territory. In 2015, the first outbreak in the Far East caused by the Coxsackie A6 virus was registered, a phylogenetic analysis of the strains of which allowed them to be identified as belonging to genotype D and assume an approximate existence of a common ancestor in 2008, which coincided with an increase in the registration of Coxsackie outbreaks of A6 infection worldwide.